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| ACETOHYDROXAMIC ACID | ||
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PRODUCT IDENTIFICATION |
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| CAS NO. | 546-88-3 |
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| EINECS NO. | 208-913-8 | |
| FORMULA | CH3CONHOH | |
| MOL WT. | 75.07 | |
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H.S. CODE |
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TOXICITY |
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| SYNONYMS | AHA; Lithostat; Methylhydroxamic acid; N-Acetylhydroxylamine; | |
| Acethydroxamsaeure; Acetic acid, oxime; Acetohydroximic acid; Acetylhydroxamic acid; Acide acetohydroxamique; Acido acetohidroxamico; Acidum acetohydroxamicum; N-Acetylhydroxylamine; N-Hydroxyacetamide; | ||
| DERIVATION |
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CLASSIFICATION |
CHELATING AGENTS / HYDROXAMIC ACIDS / |
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE | white to off-white crystalline powder | |
| MELTING POINT | 86 - 91 C | |
| BOILING POINT |
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| SPECIFIC GRAVITY | ||
| SOLUBILITY IN WATER | Soluble | |
| pH | ||
| VAPOR DENSITY |
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REFRACTIVE INDEX |
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NFPA RATINGS |
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AUTOIGNITION |
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FLASH POINT |
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| STABILITY | Stable under normal conditions. | |
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GENERAL DESCRIPTION & APPLICATIONS |
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| Hydroxamic acid is an organic compound that contains the group -C(=O)NHOH; an amine is is inserted into an carboxylic acid. This structure is useful for a variety of roles in biology and medicine. This compound can be formed by Angeli-Rimini reaction between an aldehyde and sulfinic acid or N-hydroxysulfonamide. Hydroxamic acid structure provides a variety of roles in biology and medicine (chelation therapy), It inhibits bacterial or fungi growth by interfering with iron uptake. It is also active as a inhibitor of enzyme involved in tumour growths. Marimastat is a hydroxamic acid active as an Antineoplastic by inhibiting a matrix metalloproteinase. The most characteristic property of hydroxamic acid is the metal binding (chelators). Sideromycins are hydroxamic acid compounds active as antibiotic. Siderophores are hydroxamic acid compounds produced by microorganisms for the abstraction of iron ions and dissolve these ions as soluble Fe ion complexes for active transport mechanism. Deferoxamine isolated from Streptomyces pilosus is a chelating agent used as an antidote to iron poisoning. Hydroxamic acid compounds are used as extractants for the separation of valuable metals or minerals including copper, lead, gold, other rare earth metals and kaolin. Hydroxamic acids are used to produce corresponding isocyanates by dehydration followed by rearrangement reaction. | ||
| SALES SPECIFICATION | ||
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APPEARANCE |
white to off-white crystalline powder | |
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ASSAY |
98.0% min |
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| MELTING POINT |
86 - 91 C |
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LOSS ON DRYING |
1.0% min |
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HEAVY METALS |
10ppm max | |
| TRANSPORTATION | ||
| PACKING | | |
| HAZARD CLASS | ||
| UN NO. | ||
| OTHER INFORMATION | ||
| Hazard Symbols: T, Risk Phrases: 61, Safety Phrases: 53-45 | ||
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